ME/CFS — A Comprehensive Medical Documentation

A comprehensive, open-access medical documentation of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome — a severe, chronic, multi-system neuroimmune disease affecting an estimated 0.89–2.5% of the global population.

1 The Paper

A structured reference work spanning five parts, with an epistemic classification system (achievements, hypotheses, speculations, predictions, warnings, recommendations). Available as a navigable website and downloadable PDF.

Use the sidebar to browse chapters and sections. Each page has its own table of contents. Use the accordion below to open each part, then the carousel to browse the chapters it contains and see what each one covers.

2 Recent Blog Articles

Short, accessible articles exploring specific ME/CFS topics — mechanisms, treatment reasoning, and patient-facing explanations.

How to take part in ME/CFS research
Cross-links
Research
Resources

Registers and biobanks make research possible. Here is what they are, how access works, and how patients contribute.

2026-10-03
Is the locus coeruleus the brain’s gain control?
Cross-links
Noradrenergic
Mechanisms

A theory says the locus coeruleus tunes how strongly the cortex responds — which could link a norepinephrine deficit to sensory and interoceptive amplification.

2026-10-02
The brainstem nucleus that fails first
Cross-links
Noradrenergic
Mechanisms

In Parkinson’s disease, the locus coeruleus degenerates before the substantia nigra. In ME/CFS, the same nucleus may fail — without degenerating.

2026-10-01
Do gut bacteria listen to stress hormones?
Cross-links
Noradrenergic
Mechanisms

Norepinephrine is a human stress signal. Some bacteria also grow faster when it is around. That is a two-way street rarely discussed.

2026-09-30
Cross-links worth a second look: a short series
Cross-links
Noradrenergic
Mechanisms

Four connections that fall outside the main noradrenergic thread — but are worth a look.

2026-09-29
Where our evidence is thin: a tour of the weak spots
Self-correction
Metascience
Research

A paper is only as honest as the places it admits are soft. Here are ours.

2026-09-28
The ME/CFS research landscape, mapped
Self-correction
Metascience
Research

There is now a curated register of ME/CFS research — 149 projects you can browse. Here’s what it is and why it matters.

2026-09-27
Single study, big claims: why n=16 matters
Self-correction
Metascience
Research

The norepinephrine finding that anchors an entire research thread comes from 16 patients at one centre. Here’s what that means.

2026-09-26
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