Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
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ME/CFS — A Comprehensive Medical Documentation

ME/CFS A Comprehensive Medical Documentation

A comprehensive, open-access medical documentation of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome — a severe, chronic, multi-system neuroimmune disease affecting an estimated 0.89–2.5% of the global population.

1 The Paper

A structured reference work spanning five parts, with an epistemic classification system (achievements, hypotheses, speculations, predictions, warnings, recommendations). Available as a navigable website and downloadable PDF.

Use the sidebar to browse chapters and sections. Each page has its own table of contents. Use the accordion below to open each part, then the carousel to browse the chapters it contains and see what each one covers.

2 Recent Blog Articles

Short, accessible articles exploring specific ME/CFS topics — mechanisms, treatment reasoning, and patient-facing explanations.

Acquired vs. Developmental: When ADHD-Like Features Might Be Reversible
Neurodivergence
Pathophysiology
Symptoms

Some ADHD-like features — inattention, impulsivity, executive difficulty — can arise after development rather than from it. This final part examines the evidence that adult…

2026-08-28
The Dopamine-Nrf2-NLRP3 Axis: An Inflammatory Loop Behind ADHD and Fatigue
Neurodivergence
Pathophysiology
Genetics

Low dopamine tone impairs the cell’s antioxidant-defense system, which removes a brake on the immune system’s central inflammatory switch — and the resulting inflammation…

2026-08-27
A Single Dose Failure Is Not a Verdict — Why One Null Dose Does Not Rule Out the Others
Treatment
Pharmacology
ME/CFS

“If 4 mg of LDN doesn’t work, 1 mg won’t either.” This inference rests on an unstated assumption: that a higher dose reproduces all the effects of lower doses. For a drug…

2026-08-26
The Immune and Neuroinflammatory Strand of ADHD: When Inflammation Shapes Attention
Neurodivergence
Immunology
Pathophysiology

Not all ADHD may have the same cause. A growing line of evidence links ADHD-like features to chronic neuroinflammation and microglial activation — an immune-driven process…

2026-08-26
ADHD as a Prefrontal Energy Disorder: Five Lines of Evidence, One Mechanism
Neurodivergence
Energy Metabolism
Treatment
Pathophysiology

The prefrontal cortex is the most energy-expensive region in the human brain, so it is the first to degrade under any energy scarcity. This article brings together five…

2026-08-25
The Biology of ADHD — a Series
Neurodivergence
Series
Pathophysiology

ADHD is not one thing. Four independent strands of biology — prefrontal energy, immune-driven neuroinflammation, a dopamine-Nrf2-NLRP3 axis, and acquired trajectories — can…

2026-08-24
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