Priority GPCR Autoantibody Research Directions

{These research questions are contingent on resolving the fundamental CellTrend ELISA specificity dispute (Germain 2025 null, Vernino 2022 100% control positivity). If non-specific binding is confirmed, most questions below become irrelevant. (Azcue et al. 2026).}

References

Azcue, N., A. Prada, R. Del Pino, M. Acera, T. Fernández-Valle, N. Ayo-Mentxakatorre, T. Pérez-Concha, et al. 2026. “Involvement of Autoantibodies Against G Protein-Coupled Receptors in Post-COVID Condition and Chronic Fatigue Syndrome.” Scientific Reports 16. https://doi.org/10.1038/s41598-026-49131-9.