Dorczok et al. 2025 - Dietary Supplementation for Fatigue in ME/CFS Systematic Review

Full Citation:: Dorczok MC, Mittmann G, Mossaheb N, et al. Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic Review. Nutrients. 2025;17(3):475. (Dorczok et al. 2025) DOI:: 10.3390/nu17030475 PMID:: 39940333 Study Design:: Systematic review (PRISMA), 1994-2024 Sample Size:: 14 studies (N=809) Key Findings::

- L-carnitine/guanidinoacetic acid, oxaloacetate, CoQ10+selenium, NADH showed fatigue reductions
- High risk of bias across studies (missing data, selection bias)
- 6 studies reported adverse effects (nausea, insomnia)
- No firm conclusions possible due to methodological limitations

Conclusion:: Some dietary supplements show potential but methodological flaws prevent definitive recommendations. Limitations:: High risk of bias; small sample sizes; heterogeneous interventions and outcomes. Certainty:: 0.55

References

Dorczok, Marie Celine, Gloria Mittmann, Nilufar Mossaheb, Beate Schrank, Lucie Bartova, Matthias Neumann, and Verena Steiner-Hofbauer. 2025. β€œDietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic Review.” Nutrients 17 (3): 475. https://doi.org/10.3390/nu17030475.