Epidemiology, Quality of Life, and Mortality

1 Lim et al. 2020 — Prevalence Meta-Analysis

Full Citation:: Lim E-J, Ahn Y-C, Jang E-S, Lee S-W, Lee S-H, Son C-G. Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Journal of Translational Medicine. 2020;18:100. (Lim et al. 2020) DOI:: 10.1186/s12967-020-02269-0 Key Findings::

- Pooled prevalence 0.89% (95% CI: 0.60–1.33%)
- Women 1.36% vs men 0.86%; children/adolescents 0.55%

Relevance to Part V:: Provides population-level prevalence parameters for epidemiological and predictive models.

2 Hvidberg et al. 2015 — Health-Related Quality of Life in ME/CFS

Full Citation:: Hvidberg MF, Brinth LS, Olesen AV, Petersen KD, Ehlers L. The Health-Related Quality of Life for Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). PLOS ONE. 2015;10(7):e0132421. (Hvidberg et al. 2015) DOI:: 10.1371/journal.pone.0132421 Key Findings::

- ME/CFS patients report among the lowest quality-of-life scores of any chronic disease
- EQ-5D utility values substantially below population norms

Relevance to Part V:: Provides quality-of-life outcome measures for predictive application models and cost-effectiveness analyses.

3 Jason et al. 2006 — Causes of Death in CFS

Full Citation:: Jason LA, Corradi K, Gress S, Williams S, Torres-Harding S. Causes of death among patients with chronic fatigue syndrome. Health Care for Women International. 2006;27(7):615–626. (Jason et al. 2006) DOI:: 10.1080/07399330600803766 Key Findings::

- Identified heart failure, cancer, and suicide as leading causes of death in CFS patients
- Mean age at death significantly younger than general population

Relevance to Part V:: Mortality data inform long-term outcome parameters in temporal evolution and predictive models.

4 Roberts et al. 2016 — CFS Mortality in England and Wales

Full Citation:: Roberts E, Wessely S, Chalder T, Chang C-K, Hotopf M. Mortality of people with chronic fatigue syndrome: a retrospective cohort study in England and Wales from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) Clinical Record Interactive Search (CRIS) Register. The Lancet. 2016;387(10028):1638–1643. (Roberts et al. 2016) DOI:: 10.1016/S0140-6736(15)01223-4 Key Findings::

- Retrospective cohort demonstrating excess mortality in CFS patients
- Elevated standardized mortality ratios for suicide

Relevance to Part V:: Provides empirical mortality data for long-term trajectory modeling and temporal evolution models.

5 Kingdon et al. 2018 — Functional Status Comparison with MS

Full Citation:: Kingdon CC, Bowman EA, Curran M, Nacul L, Lacerda E. Functional status and well-being in people with myalgic encephalomyelitis/chronic fatigue syndrome compared with people with multiple sclerosis and healthy controls. PharmacoEconomics – Open. 2018;2(3):281–292. (Kingdon et al. 2018) DOI:: 10.1007/s41669-018-0071-6 Key Findings::

- ME/CFS patients showed comparable or worse functional impairment than MS patients
- Demonstrates severity of ME/CFS disability relative to a well-characterized neurological condition

Relevance to Part V:: Cross-disease comparison data for model calibration and disability burden quantification.

References

Hvidberg, Michael Falk, Louise Schouborg Brinth, Anne V Olesen, Karin D Petersen, and Lars Ehlers. 2015. “The Health-Related Quality of Life for Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).” PLOS ONE 10 (7): e0132421. https://doi.org/10.1371/journal.pone.0132421.

Jason, Leonard A, Kevin Corradi, Susan Gress, Stephanie Williams, and Susan Torres-Harding. 2006. “Causes of Death Among Patients with Chronic Fatigue Syndrome.” Health Care for Women International 27 (7): 615–26. https://doi.org/10.1080/07399330600803766.

Kingdon, Caroline C, Erin A Bowman, Monica Curran, Luis Nacul, and Eliana Lacerda. 2018. “Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls.” PharmacoEconomics - Open 2 (3): 281–92. https://doi.org/10.1007/s41669-018-0071-6.

Lim, Eun-Jin, Young-Chan Ahn, Eun-Su Jang, Seung-Woo Lee, Seung-Hwan Lee, and Chang-Gue Son. 2020. “Systematic Review and Meta-Analysis of the Prevalence of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).” Journal of Translational Medicine 18: 100. https://doi.org/10.1186/s12967-020-02269-0.

Roberts, Eleanor, Simon Wessely, Trudie Chalder, Chin-Kuo Chang, and Matthew Hotopf. 2016. “Mortality of People with Chronic Fatigue Syndrome: A Retrospective Cohort Study in England and Wales from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) Clinical Record Interactive Search (CRIS) Register.” The Lancet 387 (10028): 1638–43. https://doi.org/10.1016/S0140-6736(15)01223-4.