Exercise Physiology and Post-Exertional Malaise

1 Chu et al. 2019 — Deconstructing Post-Exertional Malaise

Full Citation:: Chu L, Valencia IJ, Garvert DW, Montague MT. Deconstructing post-exertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: A patient-centered, cross-sectional survey. PLoS ONE. 2019;14(4):e0214384. (Chu et al. 2019) DOI:: 10.1371/journal.pone.0214384 Key Findings::

- Detailed patient-reported characterisation of PEM triggers, timing, and recovery
- PEM onset, duration, and severity vary by trigger type

Relevance to Part V:: PEM temporal dynamics data for parameterising temporal evolution models and PEM prediction algorithms.

2 Keller et al. 2024 — Two-Day CPET in ME/CFS

Full Citation:: Keller BA, Receno CN, Franconi CJ, et al. Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fatigue syndrome: translating reduced oxygen consumption to impairment status to treatment considerations. Journal of Translational Medicine. 2024;22(1):627. (Keller et al. 2024) DOI:: 10.1186/s12967-024-05410-5 Key Findings::

- Reduced VO~2~ on day-2 CPET confirms objective post-exertional impairment
- Translates oxygen consumption deficits to functional impairment classifications

Relevance to Part V:: Objective exercise physiology parameters for energy metabolism models; day-1 vs day-2 decline quantifies PEM.

3 Jason et al. 2009 — Energy Modulation and Physical Functioning

Full Citation:: Jason L, Benton M, Torres-Harding S, Muldowney K. The Impact of Energy Modulation on Physical Functioning and Fatigue Severity among Patients with ME/CFS. Patient Education and Counseling. 2009;77(2):237–241. (L. Jason et al. 2009) DOI:: 10.1016/j.pec.2009.02.015 Key Findings::

- Energy modulation (staying within the “energy envelope”) improves physical functioning
- Patients who exceeded their energy envelope experienced worse fatigue

Relevance to Part V:: Foundational data for energy envelope theory formalisation in modeling chapters.

4 Jason et al. 2012 — Energy Envelope Theory Interventions

[/ Full Citation:: Jason LA, Brown M, Brown A, et al. Energy Conservation/Envelope Theory Interventions to Help Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Fatigue: Biomedicine, Health & Behavior. 2012;1(1–2):27–42. (L. A. Jason et al. 2012)], DOI:: 10.1080/21641846.2012.733602 Key Findings::

- Energy envelope theory provides a framework for pacing interventions
- Staying within available energy reduces symptom severity

Relevance to Part V:: Theoretical basis for energy management models and pacing optimization algorithms.

References

Chu, Lily, Ian J Valencia, Donn W Garvert, and Michael T Montague. 2019. “Deconstructing Post-Exertional Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Patient-Centered, Cross-Sectional Survey.” PLoS ONE 14 (4): e0214384. https://doi.org/10.1371/journal.pone.0214384.

Jason, Leonard A, Molly Brown, Abigail Brown, Meredyth Evans, Samantha Flores, Elisa Grant-Holler, and Madison Sunnquist. 2012. “Energy Conservation/Envelope Theory Interventions to Help Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.” Fatigue: Biomedicine, Health & Behavior 1 (1-2): 27–42. https://doi.org/10.1080/21641846.2012.733602.

Jason, Leonard, Mary Benton, Susan Torres-Harding, and Kathleen Muldowney. 2009. “The Impact of Energy Modulation on Physical Functioning and Fatigue Severity Among Patients with ME/CFS.” Patient Education and Counseling 77 (2): 237–41. https://doi.org/10.1016/j.pec.2009.02.015.

Keller, Betsy A, Candace N Receno, Carl J Franconi, Sebastian Harenberg, Jared Stevens, Xiangling Mao, Staci R Stevens, et al. 2024. “Cardiopulmonary and Metabolic Responses During a 2-Day CPET in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Translating Reduced Oxygen Consumption to Impairment Status to Treatment Considerations.” Journal of Translational Medicine 22 (1): 627. https://doi.org/10.1186/s12967-024-05410-5.