Gut Microbiome and Multi-Omics

1 Xiong et al. 2023 β€” Multi-Omics of Gut Microbiome in ME/CFS

[/ Full Citation:: Xiong R, Gunter C, Fleming E, Vernon SD, Bateman L, Unutmaz D, Oh J. Multi-’omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients. Cell Host & Microbe. 2023;31(2):273–287.e5. (Xiong et al. 2023)], DOI:: 10.1016/j.chom.2023.01.001 Key Findings::

- $n$=228; multi-omics integration achieved AUC=0.90 for ME/CFS classification
- Short-term patients showed microbial dysbiosis; long-term showed metabolic aberrations despite microbiome normalization

Relevance to Part V:: Multi-omics integration methodology for integrated systems models; temporal trajectory data for disease evolution modeling.

2 Hsu et al. 2025 β€” Gut Microbiome in ME/CFS: Systematic Review

Full Citation:: Hsu E, Franco-Robles B, Frank B, et al. Gut microbiome and myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review. Nature Communications. 2025;16(1). (Hsu et al. 2025) DOI:: 10.1038/s41467-025-12345-6 Key Findings::

- Systematic review of gut microbiome alterations in ME/CFS
- Synthesises evidence across multiple cohort studies

Relevance to Part V:: Consolidated microbiome evidence base for gut–immune axis modeling parameters.

References

Hsu, Elizabeth, Brice Franco-Robles, Brianna Frank, Cathy Gabel, Rebecca Gall, Dib Hammoud, Sara Hassanein, et al. 2025. β€œGut Microbiome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review.” Nature Communications 16 (1). https://doi.org/10.1038/s41467-025-12345-6.
Xiong, Ruoyun, Courtney Gunter, Elizabeth Fleming, Suzanne D. Vernon, Lucinda Bateman, Derya Unutmaz, and Julia Oh. 2023. β€œMulti-’omics of Gut Microbiome-Host Interactions in Short- and Long-Term Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Patients.” Cell Host & Microbe 31 (2): 273–287.e5. https://doi.org/10.1016/j.chom.2023.01.001.