Viral Persistence and EBV Mechanisms

1 Pless et al. 2026 — EBV LMP1 and CNS Demyelination

Full Citation:: Pless A, et al. Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation. Cell. 2026. (Pless et al. 2026) DOI:: 10.1016/j.cell.2025.12.031 Key Findings::

- EBV LMP1 expression in B cells enables myelin antigen capture leading to CNS demyelination
- Demonstrates direct mechanism linking EBV to autoimmune neurological damage

Relevance to Part V:: Mechanistic basis for viral-trigger models; EBV–autoimmunity pathway for immune–neuroendocrine coupling.

References

Pless, Annika et al. 2026. “Myelin Antigen Capture in the CNS by B Cells Expressing EBV Latent Membrane Protein 1 Leads to Demyelinating Lesion Formation.” Cell. https://doi.org/10.1016/j.cell.2025.12.031.