Cardiovascular and Autonomic Dysfunction

1 Raj et al. 2005 β€” Pyridostigmine RCT in CFS

Full Citation:: Raj SR, Fennell E, Natelson BH, Frangos S, Shungu DC. Pyridostigmine in the treatment of chronic fatigue syndrome: A randomized, double-blind, placebo-controlled trial. Journal of Clinical Psychiatry. 2005;66(4):508–512. (Raj et al. 2005) DOI:: 10.4088/JCP.v66n0414 Key Findings::

- RCT of pyridostigmine (acetylcholinesterase inhibitor) for CFS
- Tested autonomic modulation as therapeutic approach

Relevance to Part V:: Autonomic intervention data for cardiovascular model calibration and cholinergic pathway modeling.

References

Raj, S R, E Fennell, B H Natelson, S Frangos, and D C Shungu. 2005. β€œPyridostigmine in the Treatment of Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.” Journal of Clinical Psychiatry 66 (4): 508–12. https://doi.org/10.4088/JCP.v66n0414.