Annotated Bibliography of ME/CFS Literature
This appendix provides a comprehensive annotated bibliography of scientific literature on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Sources are organized by research domain and include full identifying information where available. It serves as the citation-level companion to the evidence synthesized in Part IV (Research and Evidence Synthesis, opening at Chapter ME/CFS-Specific Research Methods).
1 Contents
- Primary Research: NIH Deep Phenotyping Study
- Institutional Clinical Guidelines
- Systematic Reviews and Meta-Analyses
- Pathophysiology: Immune Dysfunction
- Pathophysiology: Neurological Abnormalities
- Pain Research and Assessment
- Pathophysiology: Metabolic and Mitochondrial Dysfunction
- Pathophysiology: Gut Microbiome
- Pathophysiology: Post-Infectious Triggers — Intestinal Parasites
- Pathophysiology: Tryptophan and Serotonin Metabolism
- Pathophysiology: Viral Persistence and Reactivation
- Pathophysiology: Genetics and Epigenetics
- Biomarkers: Tetrahydrobiopterin (BH4) and Orthostatic Intolerance
- Exercise Physiology and Post-Exertional Malaise
- Treatment Evidence
- Orexin/Hypocretin System in ME/CFS and Related Conditions
- Direct Tissue Examination Findings in Long COVID and ME/CFS
- Long COVID and ME/CFS Overlap
- Historical Background and Epidemics
- Research Roadmaps and Policy Documents
- Comprehensive Reviews
- Mast Cell Activation and Antihistamine Therapies
- Severe ME/CFS: Assessment Methodology
- Blood Volume and Cardiovascular Dysfunction
- Patient-Generated Knowledge and Citizen Science
- Additional Key Resources
- Neuroimaging and Structural Brain Findings
- Neurotransmitter and Neurochemical Findings
- Prognosis and Outcomes
- Orthostatic Intolerance
- Treatment Evidence
- Coagulation and Vascular Pathology
- Lifestyle Intervention Safety
- Adenosine, Sleep Pressure, and Neuroinflammation
- EBV, Infectious Triggers, and Autoimmune Mechanisms
- Developmental Immunology and Peripheral Tolerance
- Gut-Brain Axis and Enteroendocrine Signalling
- Adolescent Neurodevelopment and Microglial Sensitive Periods
- Hematopoietic Stem Cells, Aging, and Chronic Inflammation
- Pediatric ME/CFS: Diagnosis, Management, and Prognosis
- Diagnostic Criteria, Treatment Evidence, and Mitochondrial Biology
- Diagnostic Criteria and Case Definitions
- Epidemiology, Quality of Life, and Mortality
- NIH Deep Phenotyping and Multimodal Studies
- Energy Metabolism and Mitochondrial Dysfunction
- Exercise Physiology and Post-Exertional Malaise
- Immune Dysfunction and Autoimmunity
- Neurological and Neuroendocrine Dysfunction
- Tryptophan, Kynurenine, and NAD+ Metabolism
- Riboflavin, FAD, and EGRAC
- Cofactor Panel Evidence and Systematic Reviews
- Krebs Cycle Enzyme Evidence (KGDHC, Aconitase)
- PDK/PDC Muscle Evidence and Skeletal Muscle Pathology
- Circadian Rhythm and Sleep
- Gastroparesis and Delayed Gastric Emptying
- Gut Microbiome and Multi-Omics
- Epigenetics and DNA Methylation
- Viral Persistence and EBV Mechanisms
- Cardiovascular and Autonomic Dysfunction
- Treatment: Pharmacological Interventions
- NETosis, Coagulation, and Neutrophil Dysfunction
- Autoimmunity and Post-Viral Immune Dysregulation
- Long COVID Biomarkers and Immune Profiling
- Viral Persistence
- Cellular Energy Metabolism and Fatigue
- Neuroinflammation Research Projects
- Neuroinflammation: Spike Protein Priming and Null Results
- SARS-CoV-2 Reservoir and Antiviral Strategy in Long COVID
- T Cell Immunity, Ageing, and COVID-19 Severity
- Long COVID Prevention: Vaccine Effectiveness in Pediatric Populations
- ME/CFS Blood-Based Biomarkers
- Meningitis–ME/CFS Intersection
- DecodeME Genome-Wide Association Study
- Epigenetic Clocks and DNA Methylation
- Critical Transitions and Early Warning Signals
- Long COVID Risk Factors and Prevention
- Thyroid Hormone–Mitochondrial Axis in ME/CFS
- Hyperparathyroidism as a Differential Diagnosis for ME/CFS
- Circulating Cell-Free Mitochondrial DNA in Long COVID
- Perioperative Care and Anesthesia in ME/CFS
- Vascular Pathology, RBC Dysfunction, and Endothelial Senescence (2022–2026)
- Sigma-1 Receptor Agonism, ER Stress, and Fluvoxamine in Long COVID / ME/CFS
- Neuroprotection: Lithium and ME/CFS
- Ion Channel Pathophysiology: TRPM3 in ME/CFS
- TRP Channels and Piezo Mechanosensors in ME/CFS Pathophysiology
- Pathophysiology: CSF Drainage and Glymphatic Clearance
- Blood and Immune System Convergence in ME/CFS
- Universal Disease Mechanism Families (ch17 Supporting Literature)
- TRP Channel Pentamerization and Vascular TRPV1
- Glymphatic Clearance, Norepinephrine Vasomotion, and Neurodegeneration Risk
- ANS Imbalance and Accelerated Aging
- ADHD, Neurodivergence, and Lower Metabolic Baseline as ME/CFS Predisposition
- SIBO and Gut Motility (2026-04-21)
- Hydrogen Sulfide and Mitochondrial Toxicity (2026-04-21)
- Reference Range Problem and Functional Deficiency (2026-04-21)
- Research Methodology: Blinding Bias
- Exercise Meta-Analyses: The 2025–2026 Cluster
- Functional Capacity Assessment in ME/CFS (FUNCAP)
- JCM Special Issue 2025–2026: Infection-Associated Chronic Conditions
- Ultra-Low-Dose / Microdose Lithium Literature
- Pregnancy and Reproductive Health in ME/CFS
- Female Reproductive Lifespan in ME/CFS
- Progesterone and Allopregnanolone in ME/CFS
- Epigenetics: PTPRN2 / miR-153-3p / PHB2 Axis
- Epigenetics: EpiSwitch 3D-Genomic Diagnostic — Replication, Cross-Condition Specificity, and Competing Evidence
- HSAT2 / Pericentromeric Repeat RNA and Immune Dysregulation
- MCAS–ISR Bidirectional Crosstalk
- Blood and Immune System Convergence in ME/CFS
- ADHD as Brain Energy Failure and ME/CFS Predisposition
- Gut-Derived Hydrogen Sulfide and Mitochondrial Toxicity
- Laboratory Reference Ranges and Functional Deficiency
- Systemic Sclerosis and ME/CFS: Cross-Disease Mechanisms
- HSAT2 Exosome Literature
- Exercise Recovery and Post-Exertional Malaise (PEM)
- Cryotherapy and Cold Exposure for Sleep, Pain, and Autonomic Function
- Cold Face Immersion — Diving Reflex Vagal Activation
- Wirth-Scheibenbogen Hypothesis Supporting Literature
- Butyrate and Intestinal Permeability in ME/CFS
- AI Foundation Models and Polysomnography for ME/CFS
- pDC Dysfunction and Post-Viral Biology
- Exosome-Mediated Sleep Deprivation Reversal
- Muscle Preservation in Severe/Bedbound — Relevance to ME/CFS
- Vascular Compression Syndromes: May Thurner Syndrome and ME/CFS Connections
- Thermoregulation: Heat and Cold Effects in ME/CFS
- Brain Clearance / Glymphatic System / Meningeal Lymphatics
- Sleep Duration and Biological Aging
- Inflammation Sources Registry
- Schizophrenia — Autoantibody Parallels to ME/CFS
- Cross-Disease Comparisons — Autoantibody Convergence & Diagnostic Heterogeneity
- Clinical Care Guidance for Severe ME/CFS
- HIF-2α and Post-Viral Endothelial Dysfunction
- Slow-Paced Breathing — Vagal Priming for Sleep and Autonomic Function
- Rowing Biomechanics — Ultra-Low Stroke Rate in Exercise-Intolerant Populations
- SLE—ME/CFS Overlap and Shared Fatigue Mechanisms
- GWAS/WGS Meta-Analysis and ME/CFS Genetic Studies
- Cell and Tissue Enrichment Methods and Resources
- mTOR and Autophagy
- Stigmatisation in ME/CFS
- GLP-1 Receptor Agonists and PrecisionLife Genetics in ME/CFS
- Weight Management in ME/CFS
- Narcolepsy Type 2 / Orexin System — ME/CFS Cross-Disease Literature
- Post-Exercise Recovery Optimization
- Elevated Rheumatoid Factor in ME/CFS
- Elevated Rheumatoid Factor in ME/CFS
- Emotional Processing, Interoception, and Illness Cognitions
- Dey et al. 2026 — Food Insecurity Survey in NZ ME/CFS and Long COVID
- Lin et al. 2025 — Long COVID and Food Insecurity in US Adults
- Datta et al. 2025 — Long COVID and Financial Hardship Across Socioeconomic Strata
- Feldman et al. 2025 — Social Determinants of Health and Long COVID Risk (RECOVER)
- Bowden et al. 2026 — ME/CFS Labour Market Outcomes in NZ
- Weigel et al. 2025 — Sustained Illness Burden in Australian ME/CFS
- Vester et al. 2026 — Burden of Disease in ME/CFS Scoping Review
- Samms and Ponting 2025 — Unequal Access to ME Diagnosis in England
- Aguilar-Aguilar et al. 2020 — Food Implications in Central Sensitization Syndromes
- Jones and Probst 2017 — Dietary Modification for CFS Systematic Review
- Dorczok et al. 2025 — Dietary Supplementation for Fatigue in ME/CFS Systematic Review
- Local Sleep / Waking Sleep-Like Slow Waves — Relevance to ME/CFS
- Sleep Synaptic Homeostasis / SV2A PET — Elmenhorst 2026 and Related
- Extracellular Vesicles in ME/CFS — Rydland 2026 Focus
- IgE Sensitization — Spike/Tick/Neuroinflammation (Added 2026-06-24)
- Peripheral Serotonin Depletion
- Post-COVID Ocular Syndrome
- Pupillometry as Autonomic Biomarker [pupillometry-autonomic-biomarker-mecfs]
- Ocular Sjögren / ME/CFS Overlap — Ocular Surface
- VMAT2 Loss in Striatum of Long COVID and Relevance to ME/CFS
- Glycolytic Reprogramming in the Host Response to Tick-Borne Pathogens
- Microglial Mitochondrial Dysregulation from Borrelia/Bartonella Infection
- Infection-Driven Coenzyme Q10 Depletion Hypothesis
- Maladie de Verneuil (Hidradenitis Suppurativa) and ME/CFS
- Health Technology Assessments and Government Reports
- Pharmacodiagnostic Negative-Control Class
- Pharmacodiagnostic Matrix — Diagnostic Methodology
- T-Cell Mitochondrial Exhaustion Literature
- Tier 1 Sub-Research: T-Cell Mitochondrial Exhaustion Literature Supplementation
- Chapter 35: ME/CFS-Specific Research Methods — Methodological Literature
- Research Domain: Healthcare Systems, Policy, and Disability in ME/CFS
- Global and Low-Resource Perspectives on ME/CFS
- Economic Impact of ME/CFS: Health Economics and Cost-of-Illness Research
- Charlton 2026 Muscle-Bedrest Stream
- HSV Dormancy-Undormancy Probe
- Pulsed Therapy and Tachyphylaxis Mechanisms in Chronic Illness Pharmacology
- Subjective-Measurable Discrepancy in ME/CFS
- Pharmacodiagnostic Origin Inference: Epistemology and Methodology
- Menstrual Cycle as Endogenous Pharmacodiagnostic Probe
- Contraindication Ladder — Pharmacodiagnostic Drug Interaction Framework
- Diurnal Response Window — Time-of-Day Drug Response as Pharmacodiagnostic Probe
- Fatigue–PEM Relationship: Definitional and Construct Validity Studies
- Experimental Hypoxia — Virtual Hypoxia & Brainstem Volume
- L-Theanine-Caffeine Combination for Selective Attention in ADHD
- Depression and Adult Hippocampal Neurogenesis — Literature Stream