Registry Summary

Table Registry Summary provides a compact overview of all tracked studies.

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Summary of ongoing and planned ME/CFS research studies
Study Institution Status Cohort Focus
Rosetta Stone Imperial College London Active \(n=500+\) Multi-omics: ME/CFS vs Long Covid
BioQuest Uppsala / OMF Analysis \(n=1,000\) Multi-omics biomarker panel
DecodeME Univ. Edinburgh Analysis \(n>20,000\) GWAS for ME/CFS
EpiSwitch CFS Oxford BioDynamics Validation \(n=108^*\) Epigenetic diagnostic test
BioMapAI JAX / Duke Ongoing \(n=249\) AI-integrated multi-omics
MEA PhD Project Rosalind Franklin Inst. Active TBD Metabolites, infection markers
Charité IA Charité Berlin Active TBD Immunoadsorption (autoantibodies)
BC007 Phase II Berlin Cures Analysis \(n=143\) Autoantibody neutralisation
NCNED TRPM3 Griffith Univ. Active TBD Ion channels + LDN trials
Charité fMRI Charité Berlin Funded TBD Neuroimaging biomarkers
RECOVER-TLC NIH multi-site Active \(n=600+\) Baricitinib, LDN, GLP-1, pacing
LIFT Trial Brigham Women’s Recruiting TBD LDN + pyridostigmine
Rapamycin Multi-site (US) Active TBD mTOR inhibition
Lumbrokinase Mount Sinai Recruiting TBD Fibrinolytic (microclots)
RESTORE-ME Terra Biological Published \(n=82\) Oxaloacetate (TCA cycle)
Stellate Ganglion Multi-site (US) Pilot \(n=10\) Autonomic reset (SGB)
tVNS Multi-site Recruiting TBD Vagus nerve stimulation
Masitinib AB Science Phase 2 TBD Mast cell (MCAS)
STOP-PASC/PAX LC NIH multi-site Published TBD Paxlovid (negative result)
Hydrogen Water Stony Brook Recruiting TBD Antioxidant dosing
Wearable Study Scripps Research Recruiting TBD Pacing via wearables
Added March 2026
MEA–UCL Biomarker UCL / MEA Active Biobank Blood biomarkers (neuro)
ResetME Haukeland / Oslo Recruiting \(n=66\) Daratumumab (anti-CD38)
UAB LDN U. Alabama (Younger) Recruiting TBD LDN dose-finding
Cornell NAC-GSH Weill Cornell Recruiting \(n=60\) Brain glutathione (MRS)
NSU Probiotics Nova Southeastern Recruiting \(n=100\) Microbiome / gut–brain axis
ADDRESS-LC BioVie / DoD Recruiting \(n=200\) Neuroinflammation (brain fog)
LC-REVITALIZE Western Univ. / SILC Recruiting \(n=348\) JAK1 + anti-fibrotic
CHIIME UCSF / PolyBio Recruiting TBD Viral tissue persistence
Added March 2026 (second expansion)
PrecisionLife PrecisionLife / DecodeME Published \(n>20,000\) Combinatorial genomics (250+ genes)
Cornell cfRNA Cornell Univ. Published \(n=168\) Cell-free RNA liquid biopsy
CRM Multi-modal Multi-centre (US) Published varied Energy + immune + vascular
HBOT Pilot Multi-site Published \(n=30\) Hyperbaric oxygen therapy
Palomo Herpesvirus Multi-centre Published varied EBV/HHV-6/VZV co-reactivation
Post-IM 7yr Northwestern Published \(n=4,501\) Post-mononucleosis ME/CFS cohort
RECOVER Incidence NIH multi-site Published large Post-COVID ME/CFS incidence
CD8+ T cell Atlas NIH intramural Published \(n=58\) scRNA-seq T cell exhaustion
Elahi scRNA-seq U. Alberta Published varied Immune remodelling (long COVID)
IgG Complexes Multi-centre Published varied Transfer experiment (energetics)
MCAM Autonomic CDC multi-site Published varied COMPASS-31 + lean test
SFN (Azcue) Multi-centre (Spain) Published varied Small fibre neuropathy
Microvascular Multi-centre (EU) Preprint varied Retinal vessel / endothelial
POTS Profiling Multi-centre Published varied Autonomic subtyping
2-Day CPET Multi-centre (US) Published largest PEM objective measurement
Muscle Biopsy Multi-centre (EU) Preprint varied WASF3 / ER stress in muscle
JAX Microbiome AI JAX / Duke Published \(n=249\) Gut diagnostic (90% accuracy)
Gut Composition Multi-centre Published varied Microbial dysbiosis
Steroid Hormones Multi-centre Published varied Sex-specific HPA profiling
OMF Kynurenine OMF-funded Recruiting TBD Tryptophan metabolism RCT
EDS–MCAS Multi-centre Published \(n \\approx 250\) Triad genetics/pathophysiology
Nacul LDN UBC / BC Women’s Active TBD LDN double-blind RCT
Rituximab Japan Japan Active \(n=30\) Phase 2 rituximab + imaging
Berlin Conf. 2026 ME/CFS Res. Found. May 2026 Conference (mechanisms + trials)

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* Proof-of-concept; larger validation cohorts planned.