Long COVID Risk Factors and Prevention

1 Su et al. 2022 β€” Pre-Existing Factors Predicting Long COVID

Full Citation:: Su Y, Yuan D, Chen DG, et al. Multiple early factors anticipate post-acute COVID-19 sequelae. Cell. 2022;185(5):881–895.e20. (Su et al. 2022) Key Contributions::

- Multi-omics analysis identifying four pre-existing factors predicting long COVID: autoantibodies, EBV reactivation, type 2 diabetes, and SARS-CoV-2 viremia
- Demonstrated that post-acute sequelae are partially predictable from acute-phase biomarkers

Relevance:: Directly supports the subthreshold reservoir hypothesis (Speculation Subthreshold Reservoir Population). The finding that pre-existing autoantibodies and latent viral reactivation predict post-infectious sequelae is consistent with a population sitting near the disease separatrix. Certainty Assessment::

- *Quality:* High (large multi-omics study in *Cell*)
- *Replication:* Core findings replicated in independent cohorts
- *Certainty:* 0.70

References

Su, Yapeng, Dan Yuan, Daniel G. Chen, et al. 2022. β€œMultiple Early Factors Anticipate Post-Acute COVID-19 Sequelae.” Cell 185 (5): 881–895.e20. https://doi.org/10.1016/j.cell.2022.01.014.